Critical experimental evaluation of key methods to detect, size, and quantify nanoparticolate silver
Luigi CALZOLAI (JRC Ispra)
Silver nanoparticles (AgNPs) exhibit many unique properties which are increasingly leading to their application in many areas of technology including microelectronics, pharmaceuticals, food packaging and other consumer products. As a result, there is currently a substantial regulatory activity which is driving the need to identify suitable, robust techniques to detect and quantify AgNPs dispersed in environmental and/or complex matrices.
Unfortunately, to accurately measure the nanoparticle size distribution of polydispersed samples is a complex and very difficult task.
In this presentation, different analytical techniques, Sedimentation Flow Field Fractionation (SdFFF), Asymmetrical Flow Field Flow Fractionation (AF4), Centrifugal Liquid Sedimentation (CLS) and Dynamic Light Scattering (DLS) have been used to give complementary size information about suspensions of silver nanoparticles (AgNPs) in the size range of 20-100 nm by taking advantage of the different physical principles on which are based.
