Françoise PONS
Françoise PONS
(Université de Strasbourg, France)
Professor of Toxicology at the University of Strasbourg
Address : UMR 7199, Faculté de Pharmacie, 74 route du Rhin, F-67400 Illkirch, France
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Professional experience:
- PhD in Biochemistry and Cellular and Molecular Biology, University of Montpellier II, France (1991)
- Post-doctoral position, National Heart and Lung Institute, London, UK (1991-1993)
- Post-doctoral position, Sandoz Forschungsinstitut, Vienna, Austria (1993-1994)
- Post-doctoral position, University Louis Pasteur, Strasbourg, France (1994-1995)
- Assistant-professor of Toxicology, University Louis Pasteur, Strasbourg, France (1995-2006)
Research activities:
- General research topic: lung pharmacology and toxicology
- Specific area of research: allergen and chemical-induced airway inflammatory diseases (asthma, COPD), metabolism of xenobiotics (cytochromes P450), nuclear receptors (PPAR, AhR), nanoparticles (carbon nanotubes), carbonated nanoparticles (carbon nanotubes and dots) and lipidic nanovectors (decorated liposomes for vaccination, cationic lipids for nucleic acid delivery)
- Study models: in vivo (mouse) and in vitro (airway epithelial cells, splenocytes, macrophages, dendritic cells)
Scientific production:
- Total number of publications in international journals: 61
- Most important publications during the last 5 years:
- Ronzani C, Spiegelhalter C, Vonesch JL, Lebeau L, Pons F. Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse. Arch. Toxicol. 86:137-49 (2012).
- Pierrat P, Kereselidze D, Wehrung P, Zuber G, Pons F, Lebeau L. Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA. Pharm Res. 30(5):1362-79 (2013).
- Laverny G, Casset A, Purohit A, Schaeffer E, Spiegelhalter C, de Blay F, Pons F. Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients. Toxicol. Lett. 217(2):91-101 (2013).
- Ronzani C, Casset A, Pons F. Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma. Arch Toxicol. 88(2): 489-499 (2014).
- Pierrat P, Wang R, Kereselidze D, Lux M, Didier P, Kichler A, Pons F, Lebeau L. Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials 51:290-302 (2015).
